BID - Detailed product view

Article Nr	PAT-80029-1
Description	BID, 1-195aa, Human, Recombinant, E.coli
Sizes	100ug
Source/Host	E.coli
Species Reactivity	human
MW	21, 9 kDa

Accession No		NP_001187
Alias names		FP497, MGC15319, MGC42355, BH3 interacting domain death agonist isoform 2
Purity		>95% by SDS PAGE
Sequence		MDCEVNNGSS LRDECITNLL VFGFLQSCSD NSFRRELDAL GHELPVLAPQ WEGYDELQTD GNRSSHSRLG RIEADSESQE DIIRNIARHL AQVGDSMDRS IPPGLVNGLA LQLRNTSRSE EDRNRDLATA LEQLLQAYPR DMEKEKTMLV LALLLAKKVA SHTPSLLRDV FHTTVNFINQ NLRTYVRSLA RNGMD
Concentration		1 mg/ml
Substrate/Buffer		Liquid in 20 mM Tris-HCl pH 8.0, 20% glycerol.
Storage		Store at -20 °C. Avoid freeze/thaw cycles
References		Luo, X., et al. (1998). Cell. 94:481 Li, H. et al. (1998). Cell. 94:491 Zha, J. et al. (2000). Science 290:1761
Notes		BID is a pro-apoptotic Bcl-2 protein containing only the BH3 domain. In response to apoptotic signaling, BID interacts with another Bcl-2 family protein, Bax, leading to the insertion of Bax into the outer mitochondrial membrane. Bax is believed to induce the opening of the mitochondrial voltage-dependent anion channel. This results in the release of cytochrome c and other pro-apoptotic factors from the mitochondria leading to activation of caspases. Recombinant BID protein was expressed in E.coli and purified by using conventional chromatography techniques.
Supplier		BioSite