BID - Detailed product view

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Article Nr PAT-80029-1
Description BID, 1-195aa, Human, Recombinant, E.coli
Sizes 100ug
Source/Host E.coli
Species Reactivity human
MW 21, 9 kDa
Accession No   NP_001187
Alias names   FP497, MGC15319, MGC42355, BH3 interacting domain death agonist isoform 2
Purity   >95% by SDS PAGE
Sequence   MDCEVNNGSS LRDECITNLL VFGFLQSCSD NSFRRELDAL GHELPVLAPQ
WEGYDELQTD GNRSSHSRLG RIEADSESQE DIIRNIARHL AQVGDSMDRS IPPGLVNGLA
LQLRNTSRSE EDRNRDLATA LEQLLQAYPR DMEKEKTMLV LALLLAKKVA SHTPSLLRDV
FHTTVNFINQ NLRTYVRSLA RNGMD
Concentration   1 mg/ml
Substrate/Buffer   Liquid in 20 mM Tris-HCl pH 8.0, 20% glycerol.
Storage   Store at -20 °C. Avoid freeze/thaw cycles
References   Luo, X., et al. (1998). Cell. 94:481
Li, H. et al. (1998). Cell. 94:491
Zha, J. et al. (2000). Science 290:1761
Notes   BID is a pro-apoptotic Bcl-2 protein containing only the BH3 domain. In response to apoptotic signaling, BID interacts with another Bcl-2 family protein, Bax, leading to the insertion of Bax into the outer mitochondrial membrane. Bax is believed to induce the opening of the mitochondrial voltage-dependent anion channel. This results in the release of cytochrome c and other pro-apoptotic factors from the mitochondria leading to activation of caspases. Recombinant BID protein was expressed in E.coli and purified by using conventional chromatography techniques.
Supplier   BioSite
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