BIP, 20-650aa - Detailed product view

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Article Nr PAT-80032-1
Description Recombinant human BIP, 20-650aa, His-Tagged, E.coli
Sizes 100ug
Source/Host E.coli
Species Reactivity human
MW 71 kDa
Accession No   NP_005338.1
Alias names   HSPA5 (heat shock 70kDa protein 5), GRP78 (glucose-regulated protein, 78kD), MIF2
Purity   >95% by SDS PAGE
Sequence   MEEDKKEDVG TVVGIDLGTT YSCVGVFKNG RVEIIANDQG NRITPSYVAF TPEGERLIGD AAKNQLTSNP ENTVFDAKRL IGRTWNDPSV QQDIKFLPFK VVEKKTKPYI QVDIGGGQTK TFAPEEISAM VLTKMKETAE AYLGKKVTHA VVTVPAYFND AQRQATKDAG TIAGLNVMRI INEPTAAAIA YGLDKREGEK NILVFDLGGG TFDVSLLTID NGVFEVVATN GDTHLGGEDF DQRVMEHFIK LYKKKTGKDV RKDNRAVQKL RREVEKAKRA LSSQHQARIE IESFYEGEDF SETLTRAKFE ELNMDLFRST MKPVQKVLED SDLKKSDIDE IVLVGGSTRI PKIQQLVKEF FNGKEPSRGI NPDEAVAYGA AVQAGVLSGD QDTGDLVLLD VCPLTLGIET VGGVMTKLIP RNTVVPTKKS QIFSTASDNQ PTVTIKVYEG ERPLTKDNHL LGTFDLTGIP PAPRGVPQIE VTFEIDVNGI LRVTAEDKGT GNKNKITITN DQNRLTPEEI ERMVNDAEKF AEEDKKLKER IDTRNELESY AYSLKNQIGD KEKLGGKLSS EDKETMEKAV EEKIEWLESH QDADIEDFKA KKKELEEIVQ PIISKLYGSA GPPPTGEEDT AELEHHHHHH
Concentration   1 mg/ml
Substrate/Buffer   Liquid in 20mM Tris pH 8.0, 10% glycerol
Storage   Store at -20 °C. Avoid freeze/thaw cycles
References   Lee LC., et al. (2009) Clin Chim Acta. 400(1-2):56-62.
Racek T., et al. (2008) J Biol Chem. 283(49):34305-14.
Notes   Binding immunoglobulin protein (BiP) belongs to the family of ~70 kDa heat shock proteins (HSP 70). It is a stress response protein which is induced by agents or conditions that adversely affect endoplasmic reticulum (ER) function. This protein is essential for the proper glycosylation, folding as well as for the maintenance of cell homeostasis and the prevention of apoptosis. Recombinant human BIP protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Supplier   BioSite
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