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Alias names |
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ATP-binding cassette sub-family G member 2, Placenta-specific ATP-binding cassette transporter, Breast cancer resistance protein, Mitoxantrone resistance-associated protein, CD338 antigen, CDw338, ABCP, BCRP, BCRP1, MXR
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Specificity |
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ABCG2 (N338) antibody detects endogenous levels of ABCG2 protein
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Protocol |
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WB: 1:500~1:1000 IHC: 1:50~1:200
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Substrate/Buffer |
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1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2
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Storage |
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles
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Notes |
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ATP-binding cassette (ABC) transporters are an evolutionarily conserved family of proteins that catalyze the transport of molecules across extracellular and intracellular membranes through the energy of ATP hydrolysis. The ABC halftransporter, ABCG2, is also known as placenta-specific ABC transporter and breast cancer resistance protein (BCRP1). ABCG2 confers resistance for a variety of chemotherapeutic agents, including anthracyclines, mitoxantrone, bisantrene and topotecan. Under normal conditions, ABCG2 may serve a protective function by removing toxins from the cell, and plays an important role in regulating stem cell differentiation. ABCG2 is responsible for the side population (SP) phenotype and is widely expressed in a large variety of stem cells, making it an important stem cell marker. ABCG2 may have N-linked glycosylation and may dimerize in vivo. ABCG2 is abundantly expressed in placent, a liver, intestine and stem cells
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