BCL2L2, 1-172aa - Detailed product view

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Article Nr PAT-80430-1
Description Recombinant human BCL2L2, 1-172aa, His-tag
Sizes 100ug
Source/Host E.coli
Species Reactivity human
MW 20.9 kDa (192aa)
Accession No   NP_004041
Alias names   BCL2-like protein 2, Apoptosis regulator Bcl-W, BCLW
Sequence   MGSSHHHHHH SSGLVPRGSH MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG DEFETRFRRT FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF VFGAALCAES VNKEMEPLVG QVQEWMVAYL ETRLADWIHS SGGWAEFTAL YGDGALEEAR RLREGNWASV RT
Concentration   1 mg/ml (determined by Bradford assay)
Substrate/Buffer   Liquid. In 20mM Tris-HCl buffer (pH7.5) containing 100mM NaCl, 10% glycerol
Storage   Can be stored at +4°C short term (1-2 week). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles
References   Zhu X., et al. (2004) J Neurochem. 89(5):1233-40.
Kromer G., et al. (1997) Nature Med. 3:614.
Contents/Specifications   Recombinant human BCL2L2, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Notes   BCL2-like protein 2, also known as BCL2L2, is a member of the Bcl-2 family of proteins that regulates outer mitochondrial membrane permeability. BCL2L2 is an anti apoptotic member that prevents release of cytochrome c from the mitochondria intermembrane space into the cytosol. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. It is required for normal sperm maturation.
Supplier   BioSite
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