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Alias names |
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MRX, MXR, ABCP, BCRP, BMDP, MXR1, ABC15, BCRP1, CD338, CDw338, EST157481, MGC102821
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Protocol |
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Western Bloting: 1/500 - 1/2000
Immunofluorescence: 1/200 - 1/1000
ELISA: Propose dilution 1/10000
Not yet tested in other applications. Determining optimal working dilutions by titration test.
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Substrate/Buffer |
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Ascitic fluid containing 0.03% sodium azide.
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Storage |
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Store at 4℃, for long term storage, store at -20℃.
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References |
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1. Carcinogenesis. 2008 Dec;29(12):2289-97.
2. Pharm Res. 2009 Feb;26(2):449-58.
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Notes |
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The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.Tissue specificity: Highly expressed in placenta. Low expression in small intestine, liver and colon.
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