TCL1A - Detailed product view

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Article Nr PCB-1404H
Description Recombinant Human T-cell Leukemia/lymphoma 1A
Sizes 100 µg
Format purified
Source/Host E. coli
Species Reactivity human
MW 13.4 kDa (114aa)
Accession No   NM_001098725, NP_001092195, P56279
Alias names   TCL1A; T-cell leukemia/lymphoma 1A; TCL1; T-cell lymphoma-1; T-cell lymphoma-1A; TCL-1; Oncogene TCL1; Protein p14 TCL1
Purity   > 90% by SDS – PAGE.
Sequence   MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD
Concentration   1 mg/ml (determined by Bradford assay).
Substrate/Buffer   Liquid. In 50mM Tris-HCl buffer (pH7.5) containing 10% glycerol.
Storage   Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
References   1.Herling M., et al. (2006) Leukemia. 20(2):280-5.
2.Hoyer KK., et al. (2005) J Immunol. 175(2):864-73.
Notes   TCL1A, also known as T-cell leukemia/lymphoma 1A, is a protein with a suggested role in intracellular regulation of T cell signaling. TCL1A binds to the pleckstrin homology domain of Akt (protein kinase B) family proteins, which facilitates Akt dimerization and activity. By increasing Akt activity TCL1A may enhance the serine/threonine phosphorylation of major Akt signaling substrates, such as Ikk complex, mTOR, BAD, p70S6 kinase, FOXO transcription factors, and GSK3b. These substrates regulate cellular differentiation, growth, survival, and metabolism.
Supplier   BioSite
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