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Protocol |
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Ab Production, Protein Array
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Substrate/Buffer |
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Clear, colorless solution in 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
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Storage |
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Store at -80°C.Aliquot to avoid repeated freezing and thawing.
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References |
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Developmental Shift of Cyclophilin D Contribution to Hypoxic-Ischemic Brain Injury. Wang X, Carlsson Y, Basso E, Zhu C, Rousset CI, Rasola A, Johansson BR, Blomgren K, Mallard C, Bernardi P, Forte MA, Hagberg H.J Neurosci. 2009 Feb 25;29(8):2588-96.
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Notes |
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Entrez GeneID： 581 Omim ID： 600040
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
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