Biosimilar research-grade antibodies

What Are InVivoSIM Antibodies?

Bio X Cell InVivoSIM™ antibodies are research-grade biosimilar monoclonal antibodies. Each biosimilar antibody is produced using recombinant technology and incorporates the same variable region sequence as the original pharmaceutical drug. 

Biosimilar antibodies make it possible to study the biological effects of a drug without needing to source expensive pharmaceutical-grade therapeutics. They can be used for many research applications including functional assays, flow cytometry, ELISA, Immunohistochemistry, pharmacokinetic assays, and others. 

InVivoSIM™ antibodies are offered with the same purity and in vivo formulations that Bio X Cell is known for. Our biosimilars are of exceptional quality and consistency. They are ultra-pure and free of preservatives, stabilizers, and carrier proteins, making them ideal for in vivo applications including drug efficacy studies in humanized mouse models.

InVivoSIM™ Biosimilar Antibodies Feature

  • Exceptional Purity Each lot is QC tested for purity using SDS-PAGE and are preservative, stabilizer, and carrier protein-free.
  • Binding Validation Each lot of InVivoSIM™ product is validated for antigen binding by immunoblot.
  • Ultra-low Endotoxin Levels The level of endotoxin is QC tested for each lot. Our InVivoSIM™ products are ≤ 1EU/mg. If endotoxin levels below 1EU/mg are required, please contact technical support to discuss your needs.
  • Pathogen Free Each lot of InVivoSIM™ product is screened for an exhaustive panel of murine pathogens. The results are detailed on product-specific datasheets, to help you adhere to IACUC and Animal Facility requirements.
  • Low Protein Aggregation Each lot of InVivoSIM™ product is QC tested for aggregate level and guaranteed to be below 5% of the total protein.

InVivoSIM™ Antibodies are for Research Use Only (RUO) and NOT FOR THERAPEUTIC USE.

Product Name Host Isotype Art No Recommeded Isotype Control
InVivoSIM Anti-Human TNFα (Adalimumab Biosimilar) Human Human IgG1 SIM0001 InVivoPlus Human IgG1 Isotype Control
InVivoSIM Anti-Human EGFR (Cetuximab Biosimilar) Human Human IgG1 SIM0002 InVivoPlus Human IgG1 Isotype Control
InVivoSIM Anti-Human PD-1 (Nivolumab Biosimilar) Human Human IgG4 SIM0003 InVivoMAb Human IgG4 (S228P) Isotype Control, Anti-Hen Egg Lysozyme
InVivoSIM Anti-Human CTLA-4 (Ipilimumab Biosimilar) Human Human IgG1 SIM0004 InVivoPlus Human IgG1 Isotype Control
InVivoSIM Anti-Human HER2 (Trastuzumab Biosimilar) Human Human IgG1 SIM0005 InVivoPlus Human IgG1 Isotype Control
InVivoSIM Anti-Human TNFα (Infliximab Biosimilar) Human Human IgG1 SIM0006 InVivoPlus Human IgG1 Isotype Control
InVivoSIM Anti-Human VEGF (Bevacizumab Biosimilar) Human Human IgG1 SIM0007 InVivoPlus Human IgG1 Isotype Control
InVivoSIM Anti-Human CD20 (Rituximab Biosimilar) Human Human IgG1 SIM0008 InVivoPlus Human IgG1 Isotype Control
InVivoSIM Anti-Human PD-L1 (Atezolizumab Biosimilar) Human Human IgG1 SIM0009 InVivoPlus Human IgG1 Isotype Control
InVivoSIM Anti-Human PD-1 (Pembrolimumab Biosimilar) NEW Human Human IgG4 SIM0010 InVivoMAb Human IgG4 (S228P) Isotype Control, Anti-Hen Egg Lysozyme
InVivoSIM Anti-Human C5 (Eculizumab Biosimilar) NEW Human Human IgG4 SIM0011 InVivoMAb Human IgG4 (S228P) Isotype Control, Anti-Hen Egg Lysozyme
InVivoSIM Anti-Human VEGFR-2 (Ramucirumab Biosimilar) NEW Human Human IgG1 SIM0012 InVivoPlus Human IgG1 Isotype Control
InVivoSIM Anti-Human IL-17A (Secukinumab Biosimilar) NEW Human Human IgG1 SIM0013 InVivoPlus Human IgG1 Isotype Control
InVivoSIM Anti-Human IL-6R (Tocilizumab Biosimilar) NEW Human Human IgG1 SIM0014 InVivoPlus Human IgG1 Isotype Control