BRAF V600E

The RAS/MAPK pathway (Ras-Raf-MEK-ERK signaling cascade) is involved in the regulation of cell proliferation, differentiation, and survival in response to extracellular signaling. BRAF is a member of the RAF family of protein kinases and represents one of the most frequently mutated protein kinase genes in human tumours. A mutation at nucleotide 1,799 results in the substitution of valine with glutamic acid at amino acid 600. Mutations in the braf gene is found in approximately 7%of cancers, and BRAF V600E accounts for more than 90% of these mutations.

We are now very excited to offer BRAF V600E from our new supplier, RevMab Biosciences. View product

Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, et al. Mutations of the BRAF gene in human cancer. Nature 2002;417:949–54.