Highly Specific SARS-CoV-2 Neutralizing Antibodies Detection Kit

SARS-CoV-2 Neutralizing Antibodies Detection Kit

AdipoGen Life Sciences has developed a highly specific and fast SARS-CoV-2 Neutralizing Antibodies Detection Kit that can be used to detect the presence of neutralizing antibodies against SARS-CoV-2 in serum/plasma in about 2 hours independently of species and isotypes. The SARS-CoV-2 Neutralizing Antibodies Detection Kit is an easy, safe, fast and scalable alternative to the classical neutralization assays using Vero E6 cells, such as virus neutralization test (vNT) and pseudo-virus neutralization test (pVNT) and does not need to follow biosafety requirements.

Useful Tool for SARS-CoV-2 Vaccine and Therapeutic Development

This kit is administrable in vaccine and therapeutic development as it is suitable for all antibody isotypes and can be used to test the presence of neutralizing antibodies in human and animal models. The kit is useful in current COVID-19 investigations of sero-prevalence, assessment of immune response, herd immunity, longevity of protective immunity, efficacy of different vaccine candidates as well as tracking infections in animals.

To Confirm & Characterize further SARS-CoV-2 Serological Assay Results

This Neutralizing Antibody Detection Kit is ideal to further characterize the positive anti-SARS-CoV-2 IgG antibodies, detected with the SARS-CoV-2 IgG (Spike RBD) Serological ELISA Kit.

SARS-CoV-2 (Spike RBD) IgG Serological ELISA Kit

AdipoGen Life Scienceshas developed a sensitive and specific SARS-CoV-2 (Spike RBD) IgG Serological ELISA Kit that can be used for the qualitative measurement of human Immunoglobulin G (IgG) against SARS-CoV-2 Spike (Receptor Binding Domain) protein in serum and plasma samples. Research groups have shown that by using the SARS-CoV-2 IgG Serological ELISA Kit from AdipoGen Life Sciences, false positive results can be reduced by up to 60-80% in comparison with the standard Serological IgG IVD kits available on the market.

Figure: Typical results/values taken by the new SARS-CoV-2 (Spike RBD) IgG Serological ELISA Kit

Positive Control Plate

Included in this assay kit and unique to the market for SARS-CoV-2 IgG assays, is a second plate (antigen non-coated Background Plate or False Positive Control Plate) to determine the sample specific background and to measure the amount of IgG antibodies non-specifically bound to the well. To measure presence of anti-SARS-CoV-2 human IgG antibodies in serum or plasma, net sample optical densities (Net ODs) are calculated by subtracting each sample Background Plate OD from the Spike (SARS-CoV-2) Antigen Plate (Spike Plate) OD.

Dry Blood Samples

The Assay Kit can also be used with Dry Blood Samples, which is an inexpensive and easy alternative collecting blood.

SARS-CoV-2 Spike Protein S1 (RBD) (rec.) (His)

AdipoGen Life Sciences’ SARS-CoV-2 Spike Protein S1 (RBD) (rec.) (His) is a recombinant protein which is produced in HEK 293 cells. It consists of the receptor-binding domain (RBD) of SARS-CoV-2 Spike protein S1 (aa 319-541) fused at the C-terminus to a His-tag. This protein binds to anti-SARS-CoV-2 Spike (RBD) antibodies in serum or plasma and can be used for drug and antibody screening applications and immunization. The SARS-CoV-2 Spike Protein S1 (RBD) (rec.) (His) is indeed used as antigen in the SARS-CoV-2 (Spike RBD) IgG Serological ELISA Kit to detect anti-SARS-CoV-2 Spike (RBD) antibodies in serum or plasma.