SATB2 as a marker of colorectal carcinoma

news January 07 2020

The special AT-rich sequence-binding protein 2 (SATB2) is a DNA matrix-binding protein expressed strongly in the lower gastrointestinal epithelium. SATB2 gained plenty of attention when it was shown to be a clinical marker for colorectal carcinomas. Today, more than 95% of colorectal carcinoma can be identified with SATB2 in combination with cytokeratin 20. SATB2 antibody is the first choice to distinguish primary ovarian mucinous adenocarcinomas from colorectal metastases.

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