Spark Your Study on DNA/RNA Damage

Brilliantly Investigate DNA or RNA Stress Damage

Oxidative stress damage plays an important role in the etiology and progression of a multitude of human pathologies, including oncologic, cardiovascular, and autoimmune diseases and disorders. Through reactive oxygen species (ROS), oxidative stress can result in cellular damage, enzyme inactivation, and epigenetic impairment of DNA. A better understanding of oxidative stress damage—disease relationships can therefore be beneficial for diagnostic and therapeutic purposes. As a consequence, various biomarkers have been identified for oxidative stress damage, with the most well-studied being: oxidized nucleoside derivatives like 8-hydroxy-2’-deoxyguanosine (8-OH-dG) and 8-hydroxyguanosine (8-OH-G) that are generated by ROS in cellular DNA and RNA, respectively; the ROS hydrogen peroxide (H202) and its catalyzing enzyme superoxide dismutase (SOD); and histone H2AX phosphorylation, particularly at serine 139, which manifests during the DNA damage response.

Most available methods used to investigate these biomarkers are time-consuming and have low throughput, low accuracy, and high costs. By leveraging its EpiQuik™ technologies, EpiGentek has developed a series of innovative research tools to address those issues. Our comprehensive product suite for oxidative stress damage assessment includes the following features and advantages:

  • Colorimetric/fluorometric ELISA-based assays with easy-to-follow steps for convenience and speed
  • Fast procedure
  • High sensitivity and specificity
  • Assay flexibility via strip-well microplate format for either manual or high throughput analysis
  • Simple, reliable, and consistent assay conditions

 

Choose The Right Oxidative Stress Damage Kit For Your Study

Exhibit Oxidative Stress Damage at the DNA Level

Reveal Oxidative Stress Damage at the RNA Level

Display Oxidative Stress Damage at the Cell/Tissue Extracts Level

Show Oxidative Stress Damage at the In-situ Cell Level

 

To offer you a complete repertoire of tools to use during your Oxidative Stress Damage studies, EpiGentek also provides the following for your convenience: