TotalSeq™ and Proteogenomic Analysis
Uncover unique phenotypes and understand protein expression on a single-cell level with TotalSeq™ oligo-conjugated antibodies. Seamlessly integrate these reagents into existing single-cell sequencing protocols for simultaneous characterization of protein and RNA. Explore the capabilities of proteogenomic analysis and how TotalSeq™ reagents can enable highly multiplexed single-cell protein studies for novel applications in precision medicine, oncology, immunology, neuroscience, and stem cell research.
TotalSeq™ Reagents for Single-Cell Proteogenomics
TotalSeq™ oligo-conjugated antibodies enable measurement of proteins at a single cell level and integrate seamlessly into existing single-cell RNA sequencing workflows, including Drop-Seq and those available from 10x Genomics.
Simultaneous Multiomic Data Generation: Increase the power of single cell experiments by combining proteomic and transcriptomic data.
Reduced Dropouts: In contrast to mRNA, TotalSeq™-derived antibody tags are not highly prone to dropouts, which are essentially false negative readouts.
Ultra-High Parameter Protein Detection: Detect hundreds of proteins in a single cell. A lower dropout rate contributes to enhanced sample clustering and the ability to better identify specific cell types.
Diverse applications: With a wide-range of mouse and human targets available, you can use TotalSeq™ antibodies in a variety of research areas, including:
- Personalized or Precision Medicine
- Cancer Research
- Stem Cell Research
- Basic and Applied Immunology
- Biomarker Discovery
- Characterization of New or Rare Cell Types
- Vaccine Research