Validated Antibodies against Mutated RAS Proteins
The ubiquitous HRAS, KRAS, and NRAS proto-oncoproteins are GTPase switches that play pivotal roles in cell survival and proliferation. Though tightly controlled in normal cells, RAS activity is frequently dysregulated in some developmental disorders and in many human lung, colon and pancreas carcinomas, among others. Oncogenic mutations, with almost all involving codons G12, G13, or Q61, result in constitutive RAS signaling. Understanding why certain cancers are associated with particular mutations in specific RAS proteins is an area of ongoing study. GeneTex proudly offers an outstanding selection of antibodies specific for different mutated RAS proteins.