VEGFs and Receptors: Key Mediators in Vascular and Nervous Systems

news September 30 2021

Vascular endothelial growth factors (VEGFs) are a family of secreted polypeptides with mitogenic and angiogenic activities. The importance of VEGFs and receptors in angiogenesis, tumorigenesis, and neuroprotection makes them attractive targets for drug development.

The VEGF family members VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F, and PlGF bind in specific patterns to three related receptor protein tyrosine kinases, VEGFR1/FLT1, VEGFR2/KDR, and VEGFR3/FLT4, and two non-tyrosine kinase transmembrane proteins, neuropilin-1 (NRP1) and neuropilin-2 (NRP2). The ligand-receptor binding induces the formation of homo- and heteromeric receptor complexes and activates downstream signaling. In addition to VEGF signaling, neuropilins also act as co-receptors to numerous other signaling pathways, including those triggered by Epidermal Growth Factor (EGF), Fibroblast Growth Factor (FGF), Hepatocyte Growth Factor (HGF), Insulin-like Growth Factor (IGF), Platelet-Derived Growth Factor (PDGF) and Transforming Growth Factor beta (TGFβ).

VEGF Family Ligands and Receptors

Sino Biological has over 65 recombinant VEGF & receptor proteins covering all VEGF family members and several isoforms of VEGF. A vast majority of these recombinant proteins were expressed in eukaryotic cells (human cells or insect cells), which ensures proper modification and higher activity of proteins.

High Activity

Human/Cynomolgus VEGF165
(Cat# 158-11066-HNAH)
Human KDR
(Cat# 158-10012-H08H)
Cell proliferation assay using human umbilical vein endothelial cells (HUVEC) Inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells (HUVEC)

 

Recommended Recombinant VEGF & Receptor Proteins

Cat# Molecule Species Activity Tag
158-10136-H02H VEGFR1/FLT-1 Human Active hFc
158-10136-H08H VEGFR1/FLT-1 Human Active His
158-10136-H08H1 VEGFR1/FLT-1 Human Active His
158-10806-H02H VEGFR3/FLT4 (ECD) Human Active hFc
158-50584-M02H VEGFR3/FLT-4 Mouse Active hFc
158-10012-H02H VEGFR2/KDR Human Active hFc
158-10012-H02H1 VEGFR2/KDR (Domain 1&2&3) Human Active hFc
158-10012-H02H1-B VEGFR2/KDR (Domain 1&2&3) Human hFc
158-10012-H02H2 VEGFR2/KDR (Domain 2&3) Human Active hFc
158-10012-H08H2 VEGFR2/KDR (Domain 2&3) Human His
158-10012-H20B1 VEGFR2/KDR Human Active GST & His
158-50998-M08H-B VEGFR2/KDR Mouse Active His
158-80113-R02H VEGFR2/KDR Rat Active hFc
158-80113-R08H VEGFR2/KDR Rat His
158-90907-C08H VEGFR2/KDR Cynomolgus His
158-10011-H08H NRP1 Human Active His
158-10695-H02H NRP2 Human Active hFc
158-11066-HNAB-B VEGF165 Human, Cynomolgus Native
158-11066-HNAH VEGF165 Human, Cynomolgus Active Native
158-63004-ZNAB VEGF165 Danio rerio (zebrafish) Active Native
158-70004-DNAH VEGF164 Canine Active Native
158-80006-RNAB VEGF164 Rat Active Native
158-10544-H01H VEGFB Human Active hFc
158-80103-R01H VEGFC (aa 108-223) Mouse, Rat Active hFc
158-80103-R08H VEGFC (aa 108-223) Mouse, Rat Active His
158-50157-M01H VEGFD Mouse Active hFc
158-50157-M08H VEGFD Mouse Active His
158-80104-R01H VEGFD Rat Active hFc
158-10274-H05H PIGF Human Active mFc

 

More Recombinant VEGF & Receptor Proteins

VEGFA

VEGFB

VEGFC

VEGFD

PIGF

VEGFR1/FLT-1

VEGFR2/KDR

VEGFR3/FLT-4

NRP1

NRP2

VEGF/VEGFR Antibodies

Sino Biological has over 100 antibodies against VEGF & receptor proteins with validated activities in various applications, including western blotting, ELISA, immunohistochemistry, immunofluorescence, flow cytometry, and neutralization. ELISA kits and ELISA pair sets are also available.

Antibody List of CSFs and CSFR

Anti-VEGFA

Anti-VEGFC

Anti-VEGFD

Anti-PIGF

Anti-VEGFR1/FLT-1

Anti-VEGFR2/KDR

Anti-VEGFR3/FLT-4

Anti-NRP1

Anti-NRP2

 

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