GeneTex's KO/KD-Validated Antibodies for EMT Research

Epithelial-mesenchymal transition (EMT) is a process whereby largely adherent and polarized epithelial cells acquire the phenotype of more mobile
mesenchymal cells. EMT not only facilitates morphogenesis during embryonic development but also promotes invasion and metastasis in tumors.
Pathological EMT is associated with E-cadherin repression, which has been shown to contribute to tumor progression. Several oncogenic pathways
(e.g., TGF-beta, Wnt/beta-catenin, integrins, and Notch) have been reported to induce EMT via cytoskeleton rearrangement and activation of
E-cadherin repressors, including Snail, Slug, SIP1, ZEB1, and TCF3.

GeneTex Antibodies

- Cited and independently reviewed

- Validated for multiple applications: WB, ICC/IF, IHC-P, IP, ELISA, ChIP

- Validated by Knockout/Knockdown using CRISPR- or RNAi-mediated technologies


Please see the highlighted products below.

 

Epithelial Markers

E-Cadherin antibody (GTX100443) CitationKOKDOrthogonal  ZO-1 antibody [N1N2], N-term (GTX108613) CitationKOKD  Cytokeratin 8 antibody [N1C1] (GTX112975) CitationKOKD

 

Mesenchymal Markers

   
Vimentin antibody (GTX100619) CitationKOKDOrthogonal alpha-Smooth Muscle Actin antibody (GTX100034) CitationKOKD N-Cadherin antibody (GTX127345) CitationKOKD