Ageing, neuro-immunometabolic signaling, and lipolysis
Catecholamine-induced lipolysis occurs in the context of acute inflammation to support the immune response, while chronic age-related inflammation hinders the lipolytic process. This compromise of the relationship between normal sympathetic nervous system catecholamines and adipocyte lipolysis in the elderly has detrimental metabolic repercussions. Camell et al.  investigated the underlying mechanism of this phenomenon. Using various approaches including unbiased whole-transcriptome analyses of adipose tissue macrophages (ATMs) from aged mice, they found these ATMs decrease noradrenaline bioavailability by upregulation of genes involved in catecholamine degradation through an NLRP3 inflammasome-dependent pathway. The authors suggest that modulation of the signaling between the sympathetic nervous system and ATMs may offer a novel way to ameliorate the effects of metabolic and functional decline associated with age-related chronic inflammation.
✔ Cited and independently reviewed
✔ Validated for multiple applications: WB, ICC/IF, IHC-P, EM, IP, ELISA, ChIP
✔ Validated by Knockout/Knockdown using CRISPR- or RNAi-mediated technologies
1. Nature. 2017 Sep 27. doi: 10.1038/nature24022.