Ageing, neuro-immunometabolic signaling, and lipolysis

Catecholamine-induced lipolysis occurs in the context of acute inflammation to support the immune response, while chronic age-related inflammation hinders the lipolytic process. This compromise of the relationship between normal sympathetic nervous system catecholamines and adipocyte lipolysis in the elderly has detrimental metabolic repercussions. Camell et al. [1] investigated the underlying mechanism of this phenomenon. Using various approaches including unbiased whole-transcriptome analyses of adipose tissue macrophages (ATMs) from aged mice, they found these ATMs decrease noradrenaline bioavailability by upregulation of genes involved in catecholamine degradation through an NLRP3 inflammasome-dependent pathway. The authors suggest that modulation of the signaling between the sympathetic nervous system and ATMs may offer a novel way to ameliorate the effects of metabolic and functional decline associated with age-related chronic inflammation.

GeneTex proudly offers a selection of high-quality Lipid metabolism antibodies and Catecholamine catabolism antibodies. Please see the highlighted products below.

Reliable GeneTex Antibodies for Metabolism Research

High-Quality Antibodies for Neuroscience Research

✔  Cited and independently reviewed
✔  Validated for multiple applications: WB, ICC/IF, IHC-P, EM, IP, ELISA, ChIP
✔  Validated by Knockout/Knockdown using CRISPR- or RNAi-mediated technologies  KOKD

NLRP3 / Cryopirin antibody (GTX133569)
NLRP3 / Cryopirin antibody
Monoamine Oxidase A antibody [N2C3] (GTX101289)
Monoamine Oxidase A antibody [N2C3]
Caspase 1 antibody [N1N3] (GTX101322)
Caspase 1 antibody [N1N3]
UCP1 antibody (GTX131207)
UCP1 antibody
ATGL antibody [N1C1] (GTX109941)
ATGL antibody [N1C1]
HSL antibody (GTX33957)
HSL antibody
MGL/Monoglyceride lipase antibody (GTX103517)
MGL/Monoglyceride lipase antibody
GDF3 antibody (GTX82507)
GDF3 antibody

1. Nature. 2017 Sep 27. doi: 10.1038/nature24022.