Article No
10-10007-100
Coronavirus (COVID-19) Spike
Coronavirus (COVID-19) Spike Antibody (Clone: ABM19C9)
Antibodies Primary
Specifications
| Application | ELISA, WB |
| Article No | 10-10007-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | ABM19C9 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Coronavirus (COVID-19) Spike Antibody (Clone: ABM19C9) |
| Supplier | Abeomics |
| Entrez Gene ID | 43740568 |
| Gene Symbol | S |
| Immunogen | A partial length recombinant coronavirus Spike Protein from the C-term S2 region was used as the immunogen for this antibody. (988AA-1152AA) |
| Isotype | IgG |
| Notes | The spike (S) protein of nCoV/SARS-CoV-2/COVID-19 is one of the structural glycoproteins that remains embedded in viral envelope and acts as the fundamental component of early viral infection of nCoV/SARS-CoV-2/COVID-19 upon binding the host receptor. The nCoV/SARS-CoV-2/COVID-19 has a trimeric spike protein which has two main domains such as S1 domain for receptor binding and S2 domain for membrane fusion and several specific cleavage sites in S1- S2 boundary junction that needs a novel, endocytic protease- primed cleavage to get activated during infection. It mainly binds to the furin protein on the cell membrane which performs trypsin like proteolytic cleavage and then the protein gets activated facilitating its entry into the host. This transmembrane spike protein of nCoV/SARS-CoV-2/COVID-19 shares binding property to the Angiotensin Converting Enzyme 2 (ACE2) likely to that of SARS- CoV. The high affinity of nCoV/SARS-CoV-2/COVID-19 Spike protein for human ACE2 may contribute to the apparent ease with which nCoV/SARS-CoV-2/COVID-19 can spread from human-to-human and make nCoV/SARS-CoV-2/COVID-19 pandemic. |
| Product Type | Antibodies Primary |
| Purification | Protein G Purified |
| Size | 100 µg |
| Source / Host | mouse |
| Storage | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Substrate / Buffer | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| UniProt Number | P0DTC2 |
| Product Page Updated | 2024-04-03T14:02:41.041Z |
