Article No
10-1002-F-100
DR4
Monoclonal antibody to DR4 (Clone: ABM1B11 ) FITC Conjugated
Antibodies Primary
Specifications
| Application | FC |
| Article No | 10-1002-F-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | ABM1B11 |
| Clone Type | monoclonal |
| Conjugation | FITC |
| Description | Monoclonal antibody to DR4 (Clone: ABM1B11 ) FITC Conjugated |
| Supplier | Abeomics |
| Entrez Gene ID | 8797 |
| Gene Symbol | TNFRSF10A |
| Immunogen | A partial length recombinant human DR4 protein (amino acids 2-203 was used as an immunogen for this antibody. |
| Isotype | IgG1 k |
| Keywords | Apoptosis, TNFRSF10A, 8797, O00220, TNFRSF10A, APO2, DR4, TRAILR1, ABM1B11, Monoclonal Antibody to TRAIL/DR4 Clone :ABM1B11), Anti TRAIL/DR4 Antibody, TRAIL/DR4 Antibody |
| Notes | Death receptor 4 (DR4) or TRAIL-R1, a member of the tumor necrosis factor receptor superfamily, is a cell surface receptor that triggers the apoptotic machinery upon binding to its ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. DR4 expression is enhanced by DNA damage whether induced by ionizing radiation or by chemotherapeutic agents. On binding DR4, TRAIL induces cell death via caspase-dependent apoptosis. DR4 mediate oligomeric Abeta induction of extrinsic apoptotic pathways in human microvascular cerebral endothelial cells with activation of both caspase-8 and caspase-9. It is considered a promising molecular target for cancer therapy. |
| Alias Names | TNFRSF10A||APO2||DR4||TRAILR1 |
| Product Type | Antibodies Primary |
| Protocol | Flowcytometric analysis: 0.5-1 µg/10^6 Cells |
| Purification | Protein G Purified |
| Research area | Cell Death |
| Shipping Information | Blue Ice |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Store the antibody at 4°C, stable for 6 months. Do not freeze. |
| Substrate / Buffer | 100 µg in 500 µl Tris and 0.05% sodium azide. Sodium azide is highly toxic. |
| UniProt Number | O00220 |
| Product Page Updated | 2024-04-03T14:02:41.041Z |
