Article No
10-10020-25
Application | FC, WB |
Article No | 10-10020-25 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone | ABM47B7 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | Monoclonal Antibody to Dc-Sign/CD 209 (Clone: ABM47B7) |
Supplier | Abeomics |
Entrez Gene ID | 30835 |
Gene Symbol | CD209 |
Immunogen | A recombinant protein fragment of DC-Sign protein was used as the immunogen for this antibody. |
Isotype | IgG2b k |
Keywords | Immunology, CD209, 30835, Q9NNX6, CD209, CLEC4L, ABM47B7, Monoclonal Antibody to Dc-Sign(Clone :ABM47B7), Anti Dc-Sign Antibody, Dc-Sign Antibody |
Notes | Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is a tetrameric C-type (calcium-dependent) lectin that binds, through its C-terminal carbohydrate recognition domain, high mannose N-linked glycans present on the surface of several viral glycoproteins such as human immunodeficiency virus (HIV) gp120 and hepatitis C virus (HCV) E2. It facilitates DC-specific delivery of Ag. This is accomplished by conjugating Ag to receptor-specific Ab or carbohydrate ligands that bind to its carbohydrate recognition domain. In humans, DC-SIGN expression is restricted to DCs and certain types of macrophages. DC-SIGN is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens, including viruses, bacteria, fungi, and parasites. After binding, these pathogens are internalized and pathogen-derived antigens are presented via MHC class I and II molecules to CD8+ and CD4+ T cells, respectively. DC-SIGN represents a promising CLR for targeted vaccine delivery. |
Alias Names | CD209||CLEC4L |
Product Type | Antibodies Primary |
Protocol | Western blot analysis: 0.1-0.5 µg/ml; FACS: 0.5-1 µg/10^6 Cells Reference for expression of Dc-Sign: Wai K. Lai, Phoebe J. Sun, Jie Zhang, Adam Jennings, Patricia F. Lalor, Stefan Hubscher,Jane A. McKeating,and David H. Adams. Expression of DC-SIGN and DC-SIGNR on Human Sinusoidal Endothelium Am J Pathol. 2006 Jul; 169(1): 200-208.doi: 10.2353/ajpath.2006.051191 |
Purification | Protein G Purified |
Research Area | Immunology |
Shipping Information | Blue Ice |
Size | 25 µg |
Source / Host | mouse |
Species Reactivity | human |
Storage | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
Substrate / Buffer | 25 µg in 50 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
UniProt Number | Q9NNX6 |
Product Page Updated | 2024-02-06T07:35:53.072Z |