Article No
10-10022-25
Ebola GP I
Monoclonal Antibody to Ebola GP I (Clone: ABM47F9)
Antibodies Primary
Specifications
| Application | WB |
| Article No | 10-10022-25 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | ABM47F9 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Monoclonal Antibody to Ebola GP I (Clone: ABM47F9) |
| Supplier | Abeomics |
| Entrez Gene ID | 3160774 |
| Gene Symbol | GP |
| Immunogen | A partial Length recombinant GP I protein of Sudan Ebola virus was used as an immunogen for this antibody. |
| Isotype | IgG2b k |
| Keywords | Infectious Diseases, GP, 3160774, Q7T9D9, GP, ABM47F9, Monoclonal Antibody to Ebola GP I(Clone :ABM47F9), Anti Ebola GP I Antibody, Ebola GP I Antibody |
| Notes | The Sudan ebola virus (SUDV) glycoprotein (GP) is an envelope glycoprotein that is present on the virion surface and is involved in receptor binding and mediating viral entry. It is composed of a trimer of heterodimers (GP1/GP2), where GP1 and GP2 remain covalently linked by a disulfide bond9, and the resulting GP1-GP2 pair trimerizes to form a ~450 kDa envelope spike on the viral surface. GP is synthesized as a single polypeptide of 676 amino acids in length that is post-translationally cleaved by furin to yield two subunits, GP1 and GP2. The GP1 subunit contains two heavily glycosylated domains, the glycan cap and the mucin-like domain (MLD). The glycan cap contains only N-linked glycans, whereas the MLD contains both N- and O-linked glycans. All 15 N-glycosylation sites of GP1 could be removed without compromising the expression of GP. In the endosome, a flexible loop containing GP1 residues 190 213 is cleaved by host cathepsins. This cleavage releases the glycan cap and mucin-like domains from GP1. The GP1 subunit is responsible for receptor binding and attachment to new host cells. |
| Alias Names | GP |
| Product Type | Antibodies Primary |
| Protocol | Western blot analysis: 0.5-1 µg/ml |
| Purification | Protein G Purified |
| Shipping Information | Blue Ice |
| Size | 25 µg |
| Source / Host | mouse |
| Storage | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
| Substrate / Buffer | 25 µg in 50 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| UniProt Number | Q7T9D9 |
| Product Page Updated | 2024-04-03T14:02:41.041Z |
