Article No
10-4027-100
IL-3RA
Monoclonal Antibody to IL-3RA (Clone: ABM25C1)
Antibodies Primary
Specifications
| Application | FC, WB |
| Article No | 10-4027-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | ABM25C1 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Monoclonal Antibody to IL-3RA (Clone: ABM25C1) |
| Supplier | Abeomics |
| Entrez Gene ID | 3563 |
| Gene Symbol | IL3RA |
| Immunogen | A partial length recombinant protein (a.a 120-323) of IL-3RA was used as the immunogen for this antibody. |
| Isotype | IgG2b k |
| Keywords | Immunology, IL3RA, 3563, P26951, Interleukin-3 receptor subunit alpha, IL-3 receptor subunit alpha, CD123, IL-3R-alpha, ABM25C1, Monoclonal Antibody to IL-3RA(Clone :ABM25C1), Anti IL-3RA Antibody, IL-3RA Antibody |
| Notes | Interleukin-3 receptor subunit alpha (IL-3RA) or CD123 is a high-affinity receptor for interleukin-3 (IL-3), which along with the primary signaling common β (βc) subunit (CD131) forms a heterodimer, enabling cell signaling. IL-3RA chain is a glycoprotein of 360 amino acidic residues, composed by an extracellular domain of 287 amino acid residues, involving a predicted Ig-like domain, two Fn III domains, a transmembrane domain of 30 amino acid residues and by an intracellular domain of 53 residues. It is expressed on the majority of CD34+ hemopoietic progenitors and its expression is rapidly lost during erythroid and megakaryocytic differentiation, moderately decreased during monocytic differentiation and is sustained in the granulocytic lineage. IL-3RA is also expressed in a variety of hematological neoplasms including blastic plasmacytoid dendritic cell neoplasm (BPDCN), acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), Hodgkin's lymphoma and hairy cell leukemia. |
| Alias Names | Interleukin-3 receptor subunit alpha, IL-3 receptor subunit alpha, CD123, IL-3R-alpha |
| Product Type | Antibodies Primary |
| Protocol | WB: 6-8 µg/ml, FACS: 0.5-1 µg/10^6 |
| Purification | Protein G Purified |
| Research area | Immunology |
| Shipping Information | Blue Ice |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Substrate / Buffer | 100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| UniProt Number | P26951 |
| Product Page Updated | 2024-05-08T07:23:11.080Z |
