Article No
10-4102-100
RIG-I
Monoclonal Antibody to RIG-I (Clone: ABM40B5)
Antibodies Primary
Specifications
| Application | FC, IHC, WB |
| Article No | 10-4102-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | ABM40B5 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Monoclonal Antibody to RIG-I (Clone: ABM40B5) |
| Supplier | Abeomics |
| Entrez Gene ID | 23586 |
| Gene Symbol | DDX58 |
| Immunogen | A partial length recombinant human RIG-I protein (amino acids 1-220) was used as the immunogen for this antibody. |
| Isotype | IgG1 k |
| Keywords | Immunology, DDX58, 23586, O95786, DDX58, ABM40B5, Monoclonal Antibody to RIG-I(Clone :ABM40B5), Anti RIG-I Antibody, RIG-I Antibody |
| Notes | RIG-I or Probable ATP-dependent RNA helicase DDX58 or simply DDX58 is a RNA helicase enzyme with two isoforms (106 and 101 kDa). RIG-I belongs to the DEAD/H box family and is involved in several cellular responses including RNA binding and alteration of RNA secondary structure. RIG-1 acts as sensor of viral nucleic acids thus activating a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines. Generally it remains as a monomer but upon activation by viral dsRNA it homomultimerizes and interacts with mitochondria antiviral signaling protein (MAVS/IPS1) which activating a cascade of reactions to produce specific interferon. RIG-1 is mostly expressed in vascular smooth cells. |
| Alias Names | DDX58 |
| Product Type | Antibodies Primary |
| Protocol | Western blot analysis: 2-4 µg/ml, Immunohistochemical analysis: 5 µg/ml, Flowcytometric analysis: 0.5-1µg/10^6 cells |
| Purification | Protein G Purified |
| Research area | Immunology |
| Shipping Information | Blue Ice |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Substrate / Buffer | 100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| UniProt Number | O95786 |
| Product Page Updated | 2024-04-03T14:02:41.041Z |
