Article No
10-7007-F-100
MBD1
Monoclonal Antibody to MBD1 (Clone: ABM15H2) FITC Conjugated
Antibodies Primary
Specifications
| Application | FC |
| Article No | 10-7007-F-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | ABM15H2 |
| Clone Type | monoclonal |
| Conjugation | FITC |
| Description | Monoclonal Antibody to MBD1 (Clone: ABM15H2) FITC Conjugated |
| Supplier | Abeomics |
| Entrez Gene ID | 4152 |
| Gene Symbol | MBD1 |
| Immunogen | A partial length recombinant MBD1 protein (amino acids 291-586) was used as the immunogen for this antibody. |
| Isotype | IgG1 k |
| Keywords | DNA methylation and Repair, MBD1, 4152, Q9UIS9, MBD1, CXXC3, PCM1, ABM15H2, Monoclonal Antibody to MBD1(Clone :ABM15H2), Anti MBD1 Antibody, MBD1 Antibody |
| Notes | MBD1 (Methyl-CpG-Binding Domain Protein 1) protein is a primary candidate for the readout of DNA methylation as it recruits chromatin remodelers, histone deacetylases and methylases to methylated DNA associated with gene repression. This protein, a member of a transcriptional repressor family MBD, is predominantly expressed in neurons. MBD protein binding requires both functional MBD domains and methyl-CpGs; however, some MBD proteins also bind unmethylated DNA and active regulatory regions via alternative regulatory domains or interaction with the NuRD/Mi-2 (Nucleosome Remodeling Deacetylase) complex members. The CXXC3 domain of MBD1 makes it a unique member of the MBD family due to its affinity to unmethylated DNA. MBD1 acts as an epigenetic regulator via different mechanisms, such as the formation of the MCAF1/MBD1/SETDB1 complex or the MBD1-HDAC3 complex. It also plays an important role in disease progression, contributes to the drug resistance of PC cells; however, the mechanism underlying the drug resistance endowed by MBD1 remains unknown. |
| Alias Names | MBD1||CXXC3||PCM1 |
| Product Type | Antibodies Primary |
| Protocol | FACS: 0.5-2 µg/10^6 cells |
| Purification | Protein G Purified |
| Research area | Epigenetics |
| Shipping Information | Blue Ice |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Store the antibody at 4°C, stable for 6 months. Do not freeze. |
| Substrate / Buffer | 100 µg in 500 µl Tris and 0.05% sodium azide. Sodium azide is highly toxic. |
| UniProt Number | Q9UIS9 |
| Product Page Updated | 2024-04-03T14:02:41.041Z |
