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|Country Availability||SE, FI, DK, NO, IS, EE, LV, LT|
|Data Sheet Link||https://www.abeomics.com/download_pdf.php?pID=245|
|Description||Polyclonal Antibody to 14-3-3 sigma|
|Immunogen||Full length recombinant 14-3-3 sigma protein was used as the immunogen for this antibody.|
|Notes||14-3-3 sigma is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. There are 7 known human 14-3-3 isotypes and they play important roles in many biological activities by binding to and altering the subcellular localization and/or stability of key molecules in various signaling cascades. 14-3-3 sigma was originally characterized as a human mammary epithelium marker 1 and later rediscovered as an important molecule for cell cycle checkpoint regulation. Recently it has been reported that 14-3-3 sigma may serve as a prognosis marker predicting survival of pancreatic cancer patient treatment. 14-3-3 Sigma is the only 14-3-3 isoform induced by the tumor suppressor protein p53, in response to Gamma-irradiation and other DNA-damaging agents. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression and acts as a tumor suppressor gene that is inactivated by methylation of its 5' CpG islands in epithelial tumor cells. Two isoforms of the human proteins are produced by alternative splicing.|
|Protocol||Western blot analysis: 1-3 µg/ml, Immunohistochemical analysis: 10 µg/ml|
|Purification||Protein A Chromatography|
|Source / Host||rabbit|
|Storage||Store the antibody at 4⁰C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing|
|Substrate / Buffer||25 µg in 50 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.|
|Product Page Updated||2019-01-07T14:41:25.134Z|
The delivery time for this item is approximately 5-8 business days. If other deviations occur, this will be noted on the order confirmation or communicated via email. Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.