14 -3 -3

14 -3 -3

Article No 11-1023-25
Product Type Antibodies Primary
Research Area Cell Death
Application WB
Format Purified
Size 25 µg

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Specifications

Country Availability SE, FI, DK, NO, IS, EE, LV, LT
Clone Type polyclonal
Data Sheet Link https://www.abeomics.com/download_pdf.php?pID=379
Description Polyclonal Antibody to 14-3-3
Supplier Abeomics
Immunogen A partial length recombinant 14-3-3 protein (amino acids 20-225) was used as the immunogen for this antibody.
Isotype IgG
Notes YWHAQ, also known as 14-3-3 tau (14-3-3tau) is a a phosphoserine-binding protein and a member of the 14-3-3 family of proteins. The 14-3-3 family members are dimeric phosphoserine/ phosphothreonine-binding proteins, which are involved in a very diverse spectrum of signaling pathways. YWHAQ plays a critical role in the regulation of E2F1 stability. It binds to Ser31-phosphorylated E2F1 and inhibits the ubiquitination of E2F1 during DNA damage. The binding of YWHAQ to E2F1 interferes with the function of an E31 ligase and therefore inhibits the ubiquitination and degradation of E2F1. This interaction is required for the expression and induction of several E2F1 apoptotic target genes as well as apoptosis during DNA damage.
Alias Names YWHAQ
Protocol Western blot analysis: 2-4 µg/ml
Purification Protein A Chromatography
Size 25
Size Unit µg
Source / Host rabbit
Species Reactivity human
Storage Store the antibody at 4⁰C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
Substrate / Buffer 25 µg in 50 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
UniProt Number P27348
Product Page Updated 2019-01-07T14:41:25.134Z

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Source/Host:

rabbit rabbit

Species reactivity:

human human

Product insert:

Product data sheet

Datasheet

Suggested protocols:

Western Blot

Western Blot