Chemicals & Biochemicals

(+)-AS 115

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(+)-AS 115

Article No

154-10009650-500

Size

500 µg

Shipping Information

-20

Documentation

Specifications

Additional Information A single enantiomer of a potent and selective inactivator of KIAA1363, a MAGE hydrolase an enzyme that is upregulated in aggressive cancers from various tissues (IC50 = 150 nM when tested as a racemic mixture in SK0V-3 cells); activity of the individual enantiomers of AS 115, i.e,. (+)-AS 115 and (−)-AS 115, has not been determined
Article No 154-10009650-500
Country Availability SE, FI, DK, NO, IS, EE, LV, LT, RU
Description (+)-AS 115
Supplier Cayman Chemical
Notes KIAA1363 is a 2-acetyl monoacylglyceryl ether (MAGE) hydrolase that is upregulated in aggressive cancers from various tissues.{17107} The enzyme catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network.{14603} AS 115 is a potent and selective inactivator of KIAA1363, displaying an IC50 value of 150 nM when tested as a racemic mixture in the invasive ovarian cancer cell line SKOV3.{14603} Treatment of SKOV3 cells with 10 µM AS-115 for 4 hours significantly reduced the formation of MAGE, alkyl-lysophosphatidylcholine, and alkyl-lysophosphatidic acid. The activity of the individual enantiomers of AS 115, i.e., (+)-AS 115 and (−)-AS 115, has not been determined.
Product Type Chemicals & Biochemicals
Purity ≥98%
Shipping Information -20
Size 500 µg
Storage -20
Substrate / Buffer A solution in methyl acetate
Product Page Updated 2021-02-17T10:48:22.248Z

Shipping info

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