Article No
154-11635-10
Antibiotics & Culture Media
5-Fluorocytosine
5-Fluorocytosine
Specifications
| CAS No | 2022-85-7 |
| Additional Information | An antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil, a cytotoxic drug that inhibits viral infections and has cytotoxic effects on cancer cells |
| Article No | 154-11635-10 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, RU |
| Description | 5-Fluorocytosine |
| Supplier | Cayman Chemical |
| Notes | 5-Fluorocytosine (5-FC), a fluorinated pyrimidine analog, is a synthetic antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil.{20805} 5-fluorouracil, a widely used cytotoxic drug, is further metabolized to fluorinated ribo- and deoxyribonucleotides, resulting in the inhibition of DNA and protein synthesis, which has multiple effects including inhibition of Candida species and C. neoformans infections and cytotoxicity towards cancer cells.{20805,20804} In combination with a retroviral replicating vector carrying a cytosine deaminase prodrug-activating gene, 5-FC has been shown to selectively eliminate CT26 and Tu-2449 tumor cells in vitro (IC50s = 4.2 and 1.5 μM, respectively) and to significantly improve survival and reduce tumor size (at a dose of 500 mg/kg) in two different syngeneic mouse glioma models.{20803} |
| Alias Names | 5-FC|Ancobon|Ancotil|NSC 103805|Ro 2-9915 |
| Product Type | Antibiotics & Culture Media |
| Purity | ≥95% |
| Shipping Information | -20 |
| Size | 10 g |
| Storage | -20 |
| Substrate / Buffer | A crystalline solid |
| Product Page Updated | 2021-02-17T10:48:22.248Z |
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