Proteins & Peptides

SARS-CoV-2 Surface Glycoprotein Receptor Binding Domain (rabbit IgG1 Fc-tagged)

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SARS-CoV-2 Surface Glycoprotein Receptor Binding Domain (rabbit IgG1 Fc-tagged)

Article No

154-30590

Size

100 µg

Shipping Information

-80

Documentation

Specifications

Additional Information Source: Active recombinant C-terminal rabbit IgG1 Fc-tagged SARS-CoV-2 surface glycoprotein receptor binding domain expressed in HEK293 cells • Amino acids: 319-541 • MW: 50.3 kDa
Article No 154-30590
Country Availability SE, FI, DK, NO, IS, EE, LV, LT, RU
Description SARS-CoV-2 Surface Glycoprotein Receptor Binding Domain (rabbit IgG1 Fc-tagged)
Supplier Cayman Chemical
Notes Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surface glycoprotein, also known as the spike glycoprotein, is a viral structural protein encoded by the S gene in SARS-CoV-2 RNA.{53462} SARS-CoV-2 is a member of the Betacoronavirus genus of viruses and has 88% sequence identity with two bat-derived SARS-like CoVs.{53459} The SARS-CoV-2 genome contains approximately 30 kilobases that encode four structural proteins: spike, envelope, membrane, and nucleocapsid.{53462,49555} The spike protein of SARS-CoV-2 and the related viruses SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV) is a transmembrane glycoprotein that assembles into homotrimers on the virus surface and is comprised of an N-terminal S1 subunit, which contains the receptor binding domain (RBD), and a C-terminal S2 subunit, which facilitates fusion between viral and host cell membranes.{46767,46768,49561} The 193-amino acid RBD of the SARS-CoV spike protein is a target for neutralizing antibodies.{46768,49525} The SARS-CoV-2 RBD, which spans amino acid residues 329 to 521, is 73% identical to that of SARS-CoV and can bind to human angiotensin-converting enzyme 2 (ACE2), which is the host cell surface receptor for both SARS-CoV and SARS-CoV-2.{46767,49561,49525} SARS-CoV-2 is the causative agent of the COVID-19 respiratory illness characterized by fever, cough, and shortness of breath that can progress to pneumonia and potentially death in high-risk populations.{53461} Cayman’s SARS-CoV-2 Surface Glycoprotein Receptor Binding Domain (rabbit IgG1 Fc-tagged) protein can used for ELISA, surface plasmon resonance (SPR), and Western blot (WB) applications.
Alias Names S1 RBD|SARS-CoV-2 Spike Receptor Binding Domain|Spike S1 RBD
Product Type Proteins & Peptides
Purity ≥85%
Shipping Information -80
Size 100 µg
Storage -80
Substrate / Buffer PBS, pH 7.4, with 5% mannitol, 5% trehalose, 0.01% Tween 20, and 10% glycerol
Product Page Updated 2021-02-17T10:48:22.248Z

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