Article No
155-36-097
Specifications
| Application | FA, ICC, IP |
| Article No | 155-36-097 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | 5B-12B7 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | NS5B Antibody [5B-12B7] |
| Supplier | ProSci |
| Format | Liquid |
| Immunogen | Recombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. |
| Isotype | IgG2a |
| Notes | The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs. |
| Alias Names | Nonstructural Protein 5B |
| Previous Article No | 155-36-097-100 |
| Product Type | Antibodies Primary |
| Protocol | Western Blot: (1-2ug/ml) . Optimal conditions must be determined individually for each application. |
| Purification | >95% (SDS-PAGE) |
| Research area | Immunology |
| Shipping Information | BLUE ICE |
| Size | 100 ug |
| Source / Host | mouse |
| Species Reactivity | virus |
| Storage | -20°C |
| Substrate / Buffer | Liquid. In PBS containing 0.02% sodium azide. |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
