Article No
155-36-164
Specifications
| NCBI Number | 841 |
| Accession Number | 15718704 |
| Application | ICC, IP, WB |
| Article No | 155-36-164 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | C15 |
| Clone Type | monoclonal |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Description | Caspase-8 Antibody [C15] |
| Supplier | ProSci |
| Entrez Gene ID | 841 |
| Format | Liquid |
| Gene Symbol | CASP8 |
| Immunogen | Recombinant human caspase-8 (aa 181-478). |
| Isotype | IgG2b |
| Notes | Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. At the first cleavage step, the N-terminal p43/p41 and the C-terminal p30 cleavage products are generated. Importantly, these cleavage products already possess catalytic activity. At the second cleavage step, p43/p41 and p30 are processed to p10 and p18, respectively, which leads to the generation of the active caspase-8 heterotetramer (p18/p10)2. |
| Alias Names | Apoptotic Cysteine Protease; Apoptotic Protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like Protease |
| Previous Article No | 155-36-164-100 |
| Product Type | Antibodies Primary |
| Purification | >95% (SDS-PAGE) |
| Research area | Cell Death |
| Shipping Information | BLUE ICE |
| Size | 100 ug |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | -20°C |
| Substrate / Buffer | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
| UniProt Number | Q14790 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
