Article No
155-36-165
Specifications
| NCBI Number | 16175 |
| Accession Number | 124298 |
| Application | ELISA |
| Article No | 155-36-165 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | Bamboo-2 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | IL-1alpha Antibody [Bamboo-2] |
| Supplier | ProSci |
| Entrez Gene ID | 16175 |
| Format | Liquid |
| Gene Symbol | Il1a |
| Immunogen | Recombinant mouse mature IL-1alpha. |
| Isotype | IgG1 k |
| Notes | The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner. |
| Alias Names | Interleukin-1alpha |
| Previous Article No | 155-36-165-100 |
| Product Type | Antibodies Primary |
| Protocol | ELISA: (as a detection antibody). |
| Purification | >95% (SDS-PAGE) |
| Research area | Cell Death, Immunology |
| Shipping Information | BLUE ICE |
| Size | 100 ug |
| Source / Host | mouse |
| Species Reactivity | mouse |
| Storage | -20°C |
| Substrate / Buffer | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
| UniProt Number | P01582 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
