Article No
155-36-182
Specifications
| NCBI Number | 12363 |
| Accession Number | 341940314 |
| Application | ELISA, FC, IP, WB |
| Article No | 155-36-182 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | 8A5 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Caspase-11 Antibody [8A5] |
| Supplier | ProSci |
| Entrez Gene ID | 12363 |
| Format | Liquid |
| Gene Symbol | Casp4 |
| Immunogen | Recombinant mouse caspase-11 (p20 fragment). |
| Isotype | IgG1 k |
| Notes | Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7. |
| Alias Names | Caspase-11 (mouse); Protease ICH-3 (mouse) |
| Previous Article No | 155-36-182-100 |
| Product Type | Antibodies Primary |
| Protocol | ELISA: (recombinant protein). Flow Cytometry: (overexpressed in cell lines). Immunoprecipitation: (1-5ug/ml)Western Blot: (1-2ug/ml) . Optimal conditions must be determined individually for each application. |
| Purification | >95% (SDS-PAGE) |
| Research area | Cell Death, Immunology |
| Shipping Information | BLUE ICE |
| Size | 100 ug |
| Source / Host | rat |
| Species Reactivity | mouse, rat |
| Storage | -20°C |
| Substrate / Buffer | Liquid. In PBS containing 0.02% sodium azide. |
| UniProt Number | P70343 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
