Article No
155-40-143-0.002
MMP-1 Recombinant Protein
MMP-1 Recombinant Protein
Proteins & Peptides
Specifications
| NCBI Number | 4312 |
| Accession Number | NP_001139410.1 |
| Article No | 155-40-143-0.002 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Description | MMP-1 Recombinant Protein |
| Supplier | ProSci |
| Entrez Gene ID | 4312 |
| Format | Lyophilized |
| Gene Symbol | MMP1 |
| Notes | Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-1 is a secreted collagenase with specificity toward Type I, II, III, VII, and X collagens. Recombinant human MMP-1 is a 42.7 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain which is involved in substrate specificity and in binding TIMP-1. |
| Alias Names | CLG, CLGN, CLG, Interstitial collagenase, Fibroblast collagenase, MMP-1 |
| Product Type | Proteins & Peptides |
| Purity | >90% |
| Sequence | MFVLTEGNPR WEQTHLTYRI ENYTPDLPRA DVDHAIEKAF QLWSNVTPLT FTKVSEGQAD IMISFVRGDH RDNSPFDGPG GNLAHAFQPG PGIGGDAHFD EDERWTNNFR EYNLHRVAAH ELGHSLGLSH STDIGALMYP SYTFSGDVQL AQDDIDGIQA IYGRSQNPVQ PIGPQTPKAC DSKLTFDAIT TIRGEVMFFK DRFYMRTNPF YPEVELNFIS VFWPQLPNGL EAAYEFADRD EVRFFKGNKY WAVQGQNVLH GYPKDIYSSF GFPRTVKHID AALSEENTGK TYFFVANKYW RYDEYKRSMD PGYPKMIAHD FPGIGHKVDA VFMKDGFFYF FHGTRQYKFD PKTKRILTLQ KANSWFNCRK N |
| Shipping Information | RT |
| Size | 0.002mg |
| Storage | The lyophilized MMP-1 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted MMP-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing MMP-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature. |
| Technical Specifications | MMP - 1 activity was measured by its ability to cleave a chromogenic peptide MMP - 1 substrate at room temperature. At an MMP - 1 concentration of 2.5 μg/mL, 50% cleavage was achieved at an incubation time of approximately 25 minutes |
| UniProt Number | P03956 |
| Product Page Updated | 2024-01-03T13:15:21.507Z |
