Article No
155-40-299-0.005
NCBI Number | 7132 |
Accession Number | NP_001056.1 |
Article No | 155-40-299-0.005 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Description | Soluble TNF Receptor Type I Recombinant Protein |
Supplier | ProSci |
Entrez Gene ID | 7132 |
Format | Lyophilized |
Gene Symbol | TNFRSF1A |
Notes | TNFR1 belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-α or TNF-β to TNFR1 initiates a signal transduction pathway that results in the activation of the transduction factor NFκB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFR1) is capable of inhibiting TNF-α and TNF-β activities by acting as a decoy receptor that serves as a sink for the TNF ligands. Recombinant human sTNFR1 is an 18.3 kDa protein (162 amino acid residues) comprising the cysteine rich ligand binding portion of the extracellular domain of the TNFR1 protein. |
Alias Names | FPF, MS5, p55, p60, TBP1, TNF-R, TNFAR, TNFR1, p55-R, CD120a, TNFR55, TNFR60, TNF-R-I, TNF-R55, TNFR1-d2, Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, TNF-R1 |
Product Type | Proteins & Peptides |
Purity | >98% |
Research Area | Cell Death |
Sequence | MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM GQVEISSCTV DRDTVCGCRK NQYRHYWSEN LFQCFNCSLC LNGTVHLSCQ EKQNTVCTCH AGFFLRENEC VSCSNCKKSL ECTKLCLPQI EN |
Shipping Information | RT |
Size | 0.005mg |
Storage | The lyophilized Soluble TNF Receptor Type I recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Soluble TNF Receptor Type I is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing Soluble TNF Receptor Type I recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature. |
Technical Specifications | Biological activity was determined by its inhibitory effect of the TNF - a mediated cytotoxicity in murine L - 929 cells. The ED50 for this effect in the presence of 0.25 ng/mL of recombinant human TNF - a, is 0.05 μg/mL. |
UniProt Number | P19438 |
Product Page Updated | 2024-01-03T13:15:21.507Z |