Article No
155-76-988
Specifications
| NCBI Number | 21936 |
| Application | FC |
| Article No | 155-76-988 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | DTA-1 |
| Clone Type | monoclonal |
| Concentration | batch dependent |
| Conjugation | PE |
| Description | CD357 Antibody [DTA-1] (PE) |
| Supplier | ProSci |
| Entrez Gene ID | 21936 |
| Format | Liquid |
| Gene Symbol | Tnfrsf18 |
| Isotype | IgG2b |
| Notes | The DTA-1 monoclonal antibody specifically reacts with mouse Glucocorticoid-Induced TNFR-related protein, also known as GITR and TNFRSF18, a 66-70 kDa homodimer glycoprotein, detected in the T cells treated with glucocorticoid dexamethasone. GITR is also expressed in naïve mice by CD25+/CD4+/CD8a- thymocytes and on CD25+/CD4+/CD45RB-low splenocytes. Low levels were detected in splenic CD25+/CD4+/CD45RB-low T cells, B cells, dendritic cells and macrophages. A GITR ligand was detected on dendritic cells, macrophages and B cells.The DTA-1 antibody stimulates GITR and abrogates suppression by T regulatory cells (Treg), without affecting their proliferation. DTA-1 administration or the removal of GITR-expressing cells led to organ specific autoimmune disease. |
| Alias Names | AITR, Gitr, Tnfrsf18 |
| Previous Article No | 155-76-988-0.025 |
| Product Type | Antibodies Primary |
| Purification | Affinity Purified |
| Research area | Immunology |
| Shipping Information | BLUE ICE |
| Size | 0.025 mg |
| Source / Host | rat |
| Species Reactivity | mouse |
| Storage | 4°C |
| Substrate / Buffer | Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
| UniProt Number | O35714 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
