Article No
155-90-075
ANGPTL4 Recombinant Protein
ANGPTL4 Recombinant Protein
Proteins & Peptides
Specifications
| NCBI Number | 57875 |
| Accession Number | Q9Z1P8 |
| Article No | 155-90-075 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Concentration | 1 mg/ml |
| Description | ANGPTL4 Recombinant Protein |
| Supplier | ProSci |
| Entrez Gene ID | 27329,57875 |
| Format | Liquid |
| Gene Symbol | ANGPTL3, Angptl4 |
| Notes | ANGPTL4 (Angiopoietin-like protein 4) mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorigenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7. |
| Alias Names | Angiopoietin-like Protein 4, FIAF, Fasting-induced Adipose Factor, HFARP, Hepatic Fibrinogen/Angiopoietin-related Protein |
| Previous Article No | 155-90-075-50 |
| Product Type | Proteins & Peptides |
| Protocol | This recombinant proteins is for research use only. |
| Purity | >90% |
| Sequence | Mouse ANGPTL4 (aa 1-410) is fused at the C-terminus to a DDDDK-tag. |
| Shipping Information | BLUE ICE |
| Size | 50 ug |
| Storage | -20°C |
| Substrate / Buffer | 0.2um-filtered solution in PBS. |
| Technical Specifications | Activates ERK phosphorylation in THP-1 cells. |
| UniProt Number | Q9Y5C1, Q9Z1P8 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
