Proteins & Peptides

Clusterin

NEW
Clusterin Recombinant Protein

Article No

155-96-191-0.1

Application

WB

Species Reactivity

human

Size

0.1 mg

Source / Host

human

Product insert

Suggested protocols

Specifications

MW 50.9 kDa (Disulfide – linked heterodimer)
Application WB
Article No 155-96-191-0.1
Description Clusterin Recombinant Protein
Supplier ProSci incorporated
Format Lyophilized
Notes Clusterin (CLU) is also known as dimeric acidic glycoprotein (DAG protein), testosterone repressed prostate message-2 (TRPM-2), sulfated glycoprotein-2 (SGP-2) and complement lysis inhibitor (CLI), is a secreted multifunctional glycoprotein protein which belongs to the clusterin family. Intracellular cleavages of the precursor of clusterin remove the signal peptide and generate comparably sized α and β chains which are secreted as an 80 kDa N­glycosylated disulfide­linked heterodimer. DAG protein is predominantly expressed in adult testis, ovary, adrenal gland, liver, heart, and brain and in many epithelial tissues during embryonic development. Clusterin involve in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.
Alias Names CLU, Clusterin, AAG4, APOJ, CLI, KUB1, SGP-2, SP-40, TRPM2
Product Type Proteins & Peptides
Purity >92% as determined by SDS-PAGE.
References Jones SE., et al., Int. J. Biochem. Cell Biol. 34 (5): 427–431.
Research Area Cell Death
Sequence Leu 25 - Gln 167
Size 0.1 mg
Source / Host human
Species Reactivity human
Storage Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Substrate / Buffer PBS, pH7.4
Product Page Updated 2019-05-14T13:28:56.502Z

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