Article No
155-96-750
DR5 Recombinant Protein
DR5 Recombinant Protein
Proteins & Peptides
Specifications
| MW | 40.5 kDa |
| NCBI Number | 8795 |
| Accession Number | NP_003833 |
| Application | WB |
| Article No | 155-96-750 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Description | DR5 Recombinant Protein |
| Supplier | ProSci |
| Entrez Gene ID | 8795 |
| Format | Lyophilized |
| Gene Symbol | TNFRSF10B |
| Notes | Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53. |
| Alias Names | TNFRSF10B, TRAILR2, TRAIL-R2, CD262, DR5, KILLER, TRICK2, ZTNFR9, TRICKB |
| Previous Article No | 155-96-750-0.1 |
| Product Type | Proteins & Peptides |
| Protocol | This recombinant protein can be used for WB. For research use only. |
| Purity | >95% |
| Find out more about our research areas Biochemical, Immunology, Molecular Biology and Pathology | Cell Death |
| Sequence | Ile 56 - Glu 182 |
| Shipping Information | RT |
| Size | 0.1 mg |
| Storage | -20°C, -80°C |
| Substrate / Buffer | 50 mM Tris, 100 mM NaCl, pH7.5 |
| Technical Specifications | Immobilized recombinant Human TNFSF10 at 5ug/mL (100uL/well) can bind Human DR5, Fc Tag with a linear range of 0.4-13 ng/mL (QC tested). |
| UniProt Number | O14763 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
