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|Country Availability||DK, EE, FI, FO, GL, IS, LT, LV, NO, SE|
|Data Sheet Link||http://www.prosci-inc.com/pdf.php?sku=96-781|
|Description||14-3-3 Beta Recombinant Protein|
|Notes||Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide (YWHAB) is also known as 14-3-3 protein beta, GW128, HS1. YWHAB belongs to the 14-3-3 family. YWHAB binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. YWHAB is negative regulator of osteogenesis. YWHAB blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.|
|Alias Names||YWHAB, KCIP-1, 14-3-3 beta, GW128, HS1|
|Purity||>95% as determined by SDS-PAGE.|
|References||Liu Y., et al., 2007, Mol. Endocrinol. 21:3050-3061.|
|Source / Host||bacteria|
|Storage||Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.|
|Substrate / Buffer||50 mM Tris, 150 mM NaCl, pH 7.4|
|Product Page Updated||2019-01-08T16:04:55.621Z|
The delivery time for this item is approximately 5-8 business days. If other deviations occur, this will be noted on the order confirmation or communicated via email. Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.