Article No
155-96-966
4-1BB Recombinant Protein
4-1BB Recombinant Protein
Proteins & Peptides
Specifications
| MW | 46.7 kDa |
| NCBI Number | 21942 |
| Accession Number | NP_001070976, NP_001070976.1 |
| Application | ELISA, WB |
| Article No | 155-96-966 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Description | 4-1BB Recombinant Protein |
| Supplier | ProSci |
| Entrez Gene ID | 21942 |
| Format | Lyophilized |
| Gene Symbol | Tnfrsf9 |
| Notes | 4-1BB is also known as CD137, tumor necrosis factor receptor superfamily member 9 (TNFRSF9), induced by lymphocyte activation (ILA), is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. CD137 can enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF2. |
| Alias Names | 4-1BB |
| Previous Article No | 155-96-966-$100, 155-96-966-100 |
| Product Type | Proteins & Peptides |
| Protocol | This recombinant protein can be used for E, WB. For research use only. |
| Purity | >92% |
| Research area | Immunology |
| Sequence | Val 24 - Leu 211 |
| Shipping Information | RT |
| Size | 0.1 mg |
| Storage | -20°C, -80°C |
| Substrate / Buffer | Tris with Glycine, Arginine and NaCl, pH7.5 |
| Technical Specifications | Measured by its binding ability in a functional ELISA. Immobilized Mouse B7-1, Fc Tag at 2 ug/mL (100 ul/well),can bind Mouse CTLA-4, His Tag with a linear range of 0.02-0.8 ng/mL (QC tested). |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
