Article No
155-98-681
Specifications
| NCBI Number | 12483 |
| Accession Number | P35329 |
| Application | FC |
| Article No | 155-98-681 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | 2D6 |
| Clone Type | monoclonal |
| Concentration | 0.1 mg/ml |
| Conjugation | PE/Cy5 |
| Description | CD22 Antibody [2D6] (PE-Cy5) |
| Supplier | ProSci |
| Entrez Gene ID | 12483 |
| Format | Liquid |
| Gene Symbol | Cd22 |
| Immunogen | Splenic lymphocyte plasma membranes from CBA x C57 F1 mice |
| Isotype | IgG1 |
| Notes | CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B cell activation. |
| Alias Names | Lyb-8, Leu-14, BL-CAM |
| Previous Article No | 155-98-681-0.1 |
| Product Type | Antibodies Primary |
| Protocol | CD22 Antibody [2D6] for use in flow cytometry assays. |
| Research area | Stem Cell, Immunology |
| Shipping Information | BLUE ICE |
| Size | 0.1 mg |
| Source / Host | rat |
| Species Reactivity | mouse |
| Storage | 4°C |
| Substrate / Buffer | Supplied in PBS/NaN3 and a stabilizing agent |
| Technical Specifications | CD22 Antibody [2D6] for use in flow cytometry assays. |
| UniProt Number | P35329 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
