Article No
155-98-820
Specifications
| NCBI Number | 20343 |
| Accession Number | P18337 |
| Application | FC |
| Article No | 155-98-820 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | MEL-14 |
| Clone Type | monoclonal |
| Concentration | 0.5 mg/ml |
| Conjugation | Biotin |
| Description | CD62L Antibody [MEL-14] (Biotin) |
| Supplier | ProSci |
| Entrez Gene ID | 20343 |
| Format | Liquid |
| Gene Symbol | Sell |
| Immunogen | C3H/eb cloned mouse B cell lymphoma 38C-13 |
| Isotype | IgG2a |
| Notes | CD62L, also known as L-selectin, is a type I transmembrane glycoprotein with lectin-like and epidermal growth factor-like domains. It binds to sialylated oligosaccharide determinants on high endothelial venules (HEV) in peripheral lymph nodes. In the mouse, CD62L is expressed on most thymocytes and on peripheral leukocytes, including B and T lymphocytes, neutrophils, monocytes, and eosinophils. This member of the selectin family of cell adhesion molecules appears to be required for lymphocyte homing to peripheral lymph nodes and for leukocyte extravasation at sites of inflammation. Expression of CD62L on lymphocytes and neutrophils is rapidly down-regulated upon cell activation and the level of CD62L expression, along with other markers, distinguishes naive T cells from effector/memory T cells. The monoclonal antibody MEL-14 blocks in vitro binding of lymphocytes to peripheral lymph node HEV and inhibits in vivo lymphocyte extravasation into peripheral lymph nodes and the late stages of leukocyte rolling. |
| Alias Names | L-selectin, LECAM-1, LAM-1, Ly-22, Sell, Lnhr, Lyam-1 |
| Previous Article No | 155-98-820-0.5 |
| Product Type | Antibodies Primary |
| Protocol | CD62L Antibody [MEL-14] for use in flow cytometry, immunohistochemistry, and immunoprecipitation assays. |
| Research area | Immunology |
| Shipping Information | BLUE ICE |
| Size | 0.5 mg |
| Source / Host | rat |
| Species Reactivity | mouse |
| Storage | 4°C |
| Substrate / Buffer | Supplied in PBS/NaN3 |
| Technical Specifications | CD62L Antibody [MEL-14] for use in flow cytometry, immunohistochemistry, and immunoprecipitation assays. |
| UniProt Number | P18337 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
