Article No
155-99-062
Specifications
| NCBI Number | 16185 |
| Accession Number | P16297 |
| Application | FC, IHC, IP |
| Article No | 155-99-062 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | 5H4 |
| Clone Type | monoclonal |
| Concentration | 0.5 mg/ml |
| Conjugation | Biotin |
| Description | CD122 Antibody [5H4] (Biotin) |
| Supplier | ProSci |
| Entrez Gene ID | 16185 |
| Format | Liquid |
| Gene Symbol | Il2rb |
| Immunogen | Rat myeloma YB2/0 transfected with truncated IL-2Rbeta cDNA (YB2/0-mbetat-28) |
| Isotype | IgG2a |
| Notes | The IL-2 receptor is a complex of three distinct polypeptide chains: (i) the alpha chain which binds IL-2 with low affinity; (ii) the beta chain that binds IL-2 with high affinity; and (iii) the common gamma chain (gammac) that does not bind IL-2. The high affinity receptor complex is an alpha/beta/gamma heterotrimer with a Kd of 1.3 x 10-11 M. In mouse spleen, CD122 is expresed on ~30% of CD8+ cells and all NK cells but <1% of B cells and CD4+ T lymphocytes. In the thymus, its expression is confined to CD4-CD8+ single positive and CD4-CD8- double negative cells. Cytoplasmic regions of the IL-2R beta chain are involved in IL-2-mediated cellular signaling and, via the interaction of IL-2 and its receptor complex, may be involved in the generation and differentiation of T lymphocytes. The monoclonal antibody 5H4 does not block IL-2 binding. |
| Alias Names | IL-2Rbeta, IL-15 receptor beta chain |
| Previous Article No | 155-99-062-0.5 |
| Product Type | Antibodies Primary |
| Protocol | CD122 Antibody [5H4] for use in flow cytometry and immunoprecipitation assays. |
| Shipping Information | BLUE ICE |
| Size | 0.5 mg |
| Source / Host | rat |
| Species Reactivity | mouse |
| Storage | 4°C |
| Substrate / Buffer | Supplied in PBS/NaN3 |
| Technical Specifications | CD122 Antibody [5H4] for use in flow cytometry and immunoprecipitation assays. |
| UniProt Number | P16297 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
