Proteins & Peptides

C1q, Human, Natural, 1 mg

NEW
C1q, Human, Natural, 1 mg

Article No

182-HC2123

Application

FS

Species Reactivity

human

Size

1 mg

Specifications

Application FS
Article No 182-HC2123
Description C1q, Human, Natural, 1 mg
Supplier Hycult biotechnology b.v
Additional Information Human complement protein C1q forms together with C1r and C1s the C1 macromolecule, the first component of the classical complement pathway.
Keywords Nephrology , Neurological disorders
Notes Human complement protein C1q forms together with C1r and C1s the C1 macromolecule, the first component of the classical complement pathway. Interaction of immune complexes with C1q induces a conformational change within the C1 complex, which results in activation of the classical pathway. C1q functions as recognition unit by binding to the heavy chain of IgG or IgM (Fc gamma and Fc micro) provided that the immunoglobulins are bound to their antigen. Furthermore, C1q can bind to apoptotic blebs, where it activates the classical complement pathway and mediates phagocytosis. As such, C1q promotes the clearance of apoptotic cells and subsequent exposure of auto antigens, thereby preventing stimulation of the immune system.<br>_x000D_ C1q is predominantly produced by macrophages but also by follicular dendritic cells, interdigitating cells and cells of the monocyte-macrophage lineage. C1q deficiency has a profound effect on host defence and clearance of immune complexes. Absence of C1q may cause autoimmunity by impairment of the clearance of apoptotic cells. Inherited C1q deficiency is also associated with the development of systemic lupus erythematosus (SLE).
Product Type Proteins & Peptides
Research Area Neuroscience
Size 1 mg
Species Reactivity human
Storage Product should be stored at -70 °C. Repeated freeze and thaw cycles will cause loss of activity. The exact expiry date is indicated on the label. Use C1q protein within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Product Page Updated 2019-06-11T13:10:06.481Z

Shipping info

The delivery time for this item is approximately 5-8 business days. 
If other deviations occur, this will be noted on the order confirmation or communicated via email.
Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.