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EndoCAb® IgG, Human, ELISA kit

Assay & Detection

Make a customized order

Article No

182-HK504-IGG

Application

ELISA

Species Reactivity

human

Size

1 x 96 det.

Shipping Information

Room Temperature

Article No

182-HK504-IGG

Application

ELISA

Species Reactivity

human

Size

1 x 96 det.

Shipping Information

Room Temperature

Specifications
Suggested protocols
References

Specifications

Application	ELISA
Article No	182-HK504-IGG
Country Availability	SE, FI, DK, NO, EE, LV, LT
Description	EndoCAb® IgG, Human, ELISA kit
Supplier	Hycult biotechnology
Keywords	Inflammation & Cellular Damage
Notes	The EndoCAb® IgG ELISA has been developed for determination of endotoxin core antibodies in human plasma or serum in patients or healthy individuals. Several studies show a consistent drop in postoperative levels of circulating anti-endotoxin core antibodies compared to the preoperative value. This drop has been interpreted as consumption of antibodies to endotoxin by systemic release of endotoxin. A hypothesis is that if the patients pre-operative endotoxin-core level is low, even moderately low, patients may not be able to cope with the efflux of endotoxin, which may have mild to severe clinical consequences. The assay is of interest for various experimental conditions ranging from in vitro LPS neutralization by plasma components to in vivo studies on kinetics of antibodies to endotoxin in health and diseases. The EndoCAb® standard median-units IgG (MU) are arbitrary and are based on medians of ranges for 1000 healthy adults in a particular locality. It has not been established whether normal endotoxin-core antibody values vary by region, culture or race. Users should establish appropriate local statistical controls for their studies. It is advised that studies of any patient group should always be controled by studies of appropriately selected contrasting clinical groups and/or healthy individuals recruited locally. EndoCAb® is a registered trademark. Used under license from the Scottish National Blood Transfusion Service.
Previous Article No	182-HK504-IGG, HK504-IGG
Product Type	Assay & Detection
Range	0.13 – 8 GMU/ml
Research area	Immunology
Shipping Information	Room Temperature
Size	1 x 96 det.
Species Reactivity	human
Stability	Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least six months.
Storage	Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least six months.
Product Page Updated	2024-04-05T09:42:44.568Z

Suggested protocols

ELISA

References

1. Barclay, GR; Endogenous endotoxin-core antibody (EndoCAb) as a marker of endotoxin exposure and a prognostic indicator: a review. Prog Clin Biol Res 1995, 392: 263 2. Allan, E et al; Anti-bacteroides lipopolysaccharide IgG levels in healthy adults and sepsis patients. Immunol Med Microbiol 1995, 11: 115 3. Barclay, GR, Antibodies to endotoxin in health and disease. Rev Med Midrobiol 1990, 1: 133 4. Rahman, S et al; Intestinal hypoperfusion contributes to gut barrier failure in severe acute pancreatitis. J Gastrointest Surg 2003, 7: 26 5. Eckerwall, G et al; Early nasogastric feeding in predicted severe acute pancreatitis: A clinical, randomized study. Ann Surg 2006, 244: 959 6. Redd, A et al; Microbial translocation, the innate cytokine response and HIV-1 disease progression in Africa. PNAS 2009, 106: 6718 7. Boleij, A et al; Increased Exposure to Bacterial Antigen RpL7/L12 in Early Stage Colorectal Cancer Patients. Cancer 2010, 4014 8. Pasternak, B et al; Lipopolysaccharide Exposure Is Linked to Activation of the Acute Phase Response and Growth Failure in Pediatric Crohn€™s Disease and Murine Colitis. Inflamm Bowel Dis 2010, 16: 856 9. Bukh, A et al; Endotoxemia Is Associated with Altered Innate and Adaptive Immune Responses in Untreated HIV-1 Infected Individuals. PlosOne 2011, 6: e21275 10. Mondal, D et al; Contribution of Enteric Infection, Altered Intestinal Barrier Function, and Maternal Malnutrition to Infant Malnutrition in Bangladesh. CID 2011 11. Dello, S et al; Total Intermittent Pringle Maneuver during Liver Resection Can Induce Intestinal Epithelial Cell Damage and Endotoxemia. PlosOne 2012, 7: e30539

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