Article No
182-HM2247BT-50UG
Specifications
| Application | FA, EIA, IP, IF |
| Article No | 182-HM2247BT-50UG |
| Country Availability | SE, FI, DK, NO, EE, LV, LT |
| Clone | 3C3 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | TLR4 |
| Supplier | Hycult biotechnology |
| Immunogen | CHO cells expressing chimeric human TLR4/MD-2 fusion protein |
| Isotype | IgG1 |
| Notes | The monoclonal antibody 3C3 reacts with human Toll-like receptor 4 (TLR4, CD284). TLRs belong to a family of proteins that specifically recognize and sense microbial products. They are highly conserved throughout evolution. In Drosophila, toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defences. TLRs identified as type I transmembrane signalling receptors act as innate immune recognition receptors against many pathogens. TLR4 is a functional receptor for gram-negative bacterial lipopolysaccharides (LPS). TLR4 associates with MD-2 which is absolutely required for LPS-induced activation of TLR4. TLR4 has been identified next to MD-2 and CD14 as a receptor that is central to the innate immune response to LPS of Gram-negative bacteria. The monoclonal antibody 3C3 is a TLR4 function-blocking antibody that is useful for studies on the role of TLR4 as a receptor for LPS induced cytokine production by TLR4 bearing cells. |
| Previous Article No | 182-HM2247BT, 182-HM2247BT-50UG, HM2247BT-50UG |
| Product Type | Antibodies Primary |
| Research area | Immunology |
| Shipping Information | Room Temperature |
| Size | 50µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 2 - 8 °C |
| Substrate / Buffer | 0.5 ml (100 µg/ml) 0.2 µm filtered biotinylated antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide. |
| Product Page Updated | 2023-12-29T14:10:53.573Z |
