Article No
20-1114-50
cIAP-1/HIAP-2
Polyclonal antibody to cIAP-1/HIAP-2
Antibodies Primary
Specifications
| Application | IHC, IP, WB |
| Article No | 20-1114-50 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone Type | polyclonal |
| Conjugation | Unconjugated |
| Description | Polyclonal antibody to cIAP-1/HIAP-2 |
| Supplier | Abeomics |
| Entrez Gene ID | 329 |
| Gene Symbol | BIRC2 |
| Immunogen | Full-length recombinant protein of human cAIP1 was used as immunogen for this antibody |
| Isotype | IgG |
| Notes | cIAP1 (HIAP2, MIHB) is a member of the family of inhibitor of apoptosis proteins (IAP). IAPs suppress mitochondria-dependent and -independent apoptosis by binding to and inhibiting caspases through their BIR domains (reviewed in Liston et al, 2003; Wright and Duckett, 2005). Resistance towards apoptosis is a hallmark of cancer cells, and overexpression of IAPs can contribute to the development of cancer though inhibiting apoptosis. In addition to at least one BIR domain, some IAP members also have a RING-type finger motif at their carboxyl-terminal. The RING finger domain of several IAPs, including cIAP2, have E3 ubiquitin ligase activity and target the degradation of Smac/DIABLO through ubqiuitination. Smac/DIABLO is a death inducer and functions by inhibiting IAP-caspase interactions, thereby promoting apoptosis. Degradation of cell death inducers like Smac/DIABLO is thought to be a conserved mechanism by which IAPs enhance their anti-apoptotic activity, thereby promoting cell survival. The IAPs, including cIAP1, have widespread tissue protein expression, with expression levels and subcellular localization patterns differing depending on the cell lineage (see Vischioni et al. 2005 for a comprehensive study). This antibody recognizes cIAP1, human cIAP1 is a 618 amino acid protein. |
| Alias Names | BIRC2||API1||IAP2||MIHB||RNF48 |
| Product Type | Antibodies Primary |
| Protocol | WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200 |
| Research area | Cell Death |
| Shipping Information | Blue Ice |
| Size | 50 µl |
| Source / Host | rabbit |
| Species Reactivity | dog/canine, human, mammals, mouse, rat |
| Storage | Store the antibody at 4⁰C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Substrate / Buffer | 50 µl sera |
| UniProt Number | Q13490 |
| Product Page Updated | 2024-04-03T14:02:41.041Z |
