Article No
246-MUB2049P
Mouse anti Human CD106
Mouse anti Human CD106
Antibodies Primary
Specifications
| Application | FC |
| Article No | 246-MUB2049P |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | B-K9 |
| Clone Type | monoclonal |
| Description | Mouse anti Human CD106 |
| Supplier | Nordic - MUbio |
| Format | Each vial contains 100µl 1mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide. |
| Isotype | IgG1 |
| Notes | CD106 is a 110kDa type 1 transmembrane sialoglycoprotein, which is also known as vascular cell adhesion molecule 1 (VCAM-1). The CD106 protein is primarily expressed on activated vascular endothelium but has also been detected on dendritic cell types, macrophages and non-vascular cells in certain tissues. Expression of CD106 is induced by inflammatory stimuli and cytokines. CD106 binds to the integrins CD49d/CD29 (also known as VLA4) and alpha4beta7 and is important in leucocyte-endothelial cell adhesion and signal transduction. The CD106 protein is thought to play a key role in the migration of leucocyte from the blood into tissues, particularly at sites of inflammation. Studies suggest that CD106 may also play a role in the development of rheumatoid arthritis and atherosclerosis. |
| Previous Article No | 246-MUB2049P |
| Product Type | Antibodies Primary |
| Protocol | The antibody produced by clone B-K9 can be used for CD106 cell identification, quantification and isolation by flow cytometry. The antibody has also been reported for use in blocking studies. For this application, please request a sodium azide free antibody format. Optimal antibody dilutions for the different applications should be determined by titration. The recommended range for flow cytometry is 1:100 – 1:200. |
| Research area | Immunology |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | The antibody is shipped at ambient temperature and may be stored at +4°C. For prolonged storage prepare appropriate aliquots and store at or below -20°C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at +4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product. |
| Substrate / Buffer | Each vial contains 100µl 1mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide. |
| Technical Specifications | Each vial contains 100µl 1mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide. |
| UniProt Number | P19320 |
| Product Page Updated | 2024-01-31T10:35:40.347Z |
