Article No
30-1368-0.1
Application | FC, IHC |
Article No | 30-1368-0.1 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone | HM57 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | Anti-CD79a Monoclonal Antibody (Clone:HM57) |
Supplier | Abeomics |
Entrez Gene ID | 973 |
Gene Symbol | CD79A |
Immunogen | Synthetic peptide corresponding to amino acids 202-216 of human CD79a |
Isotype | IgG1 |
Notes | CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling. |
Alias Names | CD79A||IGA||MB1 |
Product Type | Antibodies Primary |
Protocol | Flow Cytometry Recommended dilution:5 µg/ml Application note: intracellular staining Immunohistochemistry Recommended dilution:10 µg/ml Immunohistochemistry (frozen sections) Recommended dilution:10 µg/ml |
Purification | Protein A Purified |
Shipping Information | Blue Ice |
Size | 0.1 mg |
Source / Host | mouse |
Species Reactivity | chicken, cow/bovine, guinea pig, horse/equine, human, mammals, mouse, pig/porcine, rabbit, rat |
Storage | 4°C |
UniProt Number | P11912 |
Product Page Updated | 2024-02-06T07:35:53.072Z |